The overall goal of CATCH ALL is to integrate comprehensive information from adult and pediatric ALL patients to better understand the molecular and immunological mechanisms driving leukemia persistence and MRD for clinical translation. We therefore propose the following specific scientific objectives, which are closely interconnected.
- To determine molecular characteristics defining age-specific divergent treatment responses and clonal evolution in BCP-ALL and BCP-L and to explore oncogenic driver networks in functional models relevant to all ages (P1, P2, P4)
- To identify mechanisms of leukemia-specific and immunological control of MRD in ALL (P3)
- To explore novel T cell and antibody-based strategies for the immunological control of ALL (P5, P6, P7)
- To establish a structural environment for data generation/development, data handling and bioinformatics (INF) as well as a clinical platform for translation and back-translation of therapeutic interventions and for structured education (Z)