Dr. med. Lorenz Bastian

Facts

Phone: +49-431-500-22531
E-Mail: lorenz.bastian@uksh.de
Website:
www.uksh.de/med2-kiel
Affiliations: Clinic for Internal Medicine II, Hematology and Oncology / University Medical Center Schleswig-Holstein, Campus Kiel
Address: Arnold-Heller-Str. 3, Bldg L, 24105 Kiel

Curriculum vitae

Education/Training

Since 2020Head of the Molecular Tumor Board, Campus Kiel
University Cancer Center Schleswig-Holstein, Kiel, Germany 
Since 2019 Residency Internal Medicine and Hematology / Oncology, Clinic for Internal Medicine II, University Medical Center Schleswig-Holstein, Kiel, Germany 
2012-2018 Residency Internal Medicine and Hematology / Oncology, Department of Medicine, Division of Hematology and Oncology, Charité – University Hospital Berlin, Germany  
2012 Residency Internal Medicine, Department of Medicine, University Hospital Basel, Basel, Switzerland 
2009-2012 Residency Pediatric Oncology and Hematology, Department of Pediatrics, Divison of Hematology and Oncology, Charité – University Hospital Berlin, Germany 
2008 M. D. University Witten/Herdecke, Witten, Germany 

Research Experience/Academic Appointments 

Since 2019 Senior Clinician Scientist, Research Group Functional Genomics of Acute Leukemias (AG Prof. Dr. med. Claudia Baldus), University Medical Center Schleswig-Holstein, Kiel, Germany
2015-2018 Clinician Scientist, Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany, Research Group Translational Leukemia Research, Charité – University Hospital Berlin, Germany and Fellow, DKTK School of Oncology, German Cancer Consortium, Heidelberg, Germany 
2016-2018 DKTK Investigator, German Cancer Consortium and German Cancer Research Center, Berlin and Heidelberg, Germany 
2008-2014 Doctoral and Post-doctoral Researcher, Department of Pediatrics, Division of Hematology and Oncology, Charité – University Hospital Berlin, Germany

Important Scientific Prizes/Functions 

2019 Poster prize, EMBO Workshop on “B cell development and leukemia”, Salamanca, Spain 
2017  ASH Abstract Achievement Award, American Society of Hematology, Atlanta, USA 
2015  ASH Abstract Achievement Award, American Society of Hematology, Orlando, USA 

Research groups

Project-related publications

P1, P3, P4, INF, Z

The Gene Expression Classifier ALLCatchR Identifies B-cell Precursor ALL Subtypes and Underlying Developmental Trajectories Across Age

Beder T, Hansen BT, Hartmann AM, Zimmermann J, Amelunxen E, Wolgast N, Walter W, Zaliova M, Antić Ž, Chouvarine P, Bartsch L, Barz MJ, Bultmann M, Horns J, Bendig S, Kässens J, Kaleta C, Cario G, Schrappe M, Neumann M, Gökbuget N, Bergmann AK, Trka J, Haferlach C, Brüggemann M, Baldus CD, Bastian L.

PubMed (PMID: 37645423)
HemaSphere
2023
P1, P3, P4, Z, INF

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.

Bastian L, Beder T, Barz MJ, Bendig S, Bartsch L, Walter W, Wolgast N, Brändl B, Rohrandt C, Hansen BT, Hartmann AM, Iben K, Das Gupta D, Denker M, Zimmermann J, Wittig M, Chitadze G, Neumann M, Schneller F, Fiedler W, Steffen B, Stelljes M, Faul C, Schwartz S, Müller FJ, Cario G, Harder L, Haferlach C, Pfeifer H, Gökbuget N, Brüggemann M, Baldus CD.

PubMed (PMID: 38153913)
Blood
2023
P1, P3, P4, INF, Z

UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment

Bastian L, Hartmann AM, Beder T, Hänzelmann S, Kässens J, Bultmann M, Hoeppner MP, Franzenburg S, Wittig M, Franke F, Nagel I, Spielmann M, Reimer N, Busch H, Schwartz S, Steffen B, Viardot A, Döhner K, Kondakci M, Wulf G,  Wendelin K, Renzelmann A, Kiani A, Trautmann H, Neumann M, Gökbuget N, Brüggemann M, Baldus CD

PubMed (PMID: 35397658)
Leukemia
2022
P1, P4, INF

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, Raifer H, Menke L, Hansal L, Camara B, Roth E,  Daum P, Wanzel M, Mernberger M, Nist A, Bauer UM, Helmprobst F, Buchholz M, Roth K, Bastian L, Hartmann AM, Baldus C, Ikuta K, Neubauer A, Burchert A, Jäck HM, Klein M, Bopp T, Stiewe T, Pagenstecher A, Lohoff M

PubMed (PMID: 35459909)
Cell Death Differ.
2022
P1, P3, P4, Z

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

Schroeder MP, Bastian L, Eckert C, Gökbuget N, James AR, Tanchez JO, Schlee C, Isaakidis K, Häupl B, Baum K, Migueles Lozano OA, Kouidri K, Pan KT, Urlaub H, Schwartz S, Burmeister T, von Stackelberg A, Hoelzer D, Pfeiffer H, Rieger MA, Göllner S, Oellerich T, Horstmann M, Schrappe M, Wolf J, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Neumann M, Baldus CD

PubMed (PMID: 30862934)
Sci Rep
2019
P1, P3, P4, Z

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

Schroeder MP, Bastian L, Eckert C, Gökbuget N, James AR, Tanchez JO, Schlee C, Isaakidis K, Häupl B, Baum K, Migueles Lozano OA, Kouidri K, Pan KT, Urlaub H, Schwartz S, Burmeister T, von Stackelberg A, Hoelzer D, Pfeiffer H, Rieger MA, Göllner S, Oellerich T, Horstman M, Schrappe M, Wolf J, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Neumann M, Baldus CD

PubMed (PMID: 30862934)
Sci Rep
2019

Participating Institutes